Does frozen semaglutide still work?

Semaglutide should not be frozen. Freezing can damage the peptide and the medication should be discarded if it has been frozen — do not use it, even after thawing. Semaglutide is designed to be refrigerated (roughly 36–46°F / 2–8°C), and once frozen its potency and safety can no longer be assured.

Why freezing is a problem

Semaglutide is a peptide. Freezing can cause the protein structure to break down and can compromise the sterile formulation, which may reduce effectiveness. Manufacturers and pharmacies direct patients to discard semaglutide that has been frozen rather than risk an underdosed or degraded product.

What to do

If your medication froze in transit or in the fridge, do not inject it — contact your pharmacy or GOAL.MD care team for guidance on a replacement. Store semaglutide in the refrigerator, away from the freezer coils and back wall where temperatures dip lowest.

Medically reviewed by Dr. Michael Mimlitz, MD (NPI 1508891870), Chief Physician of GOAL.MD. Physician-supervised telehealth. More at goal.md/answers.