How long can semaglutide be left out of the refrigerator?

Guidance varies by product, but many semaglutide pens and vials can tolerate room temperature (up to about 86°F / 30°C) for a limited window — often cited as up to 28 days for some brand pens once in use. Compounded formulations may differ. Always follow the specific storage instructions provided with your medication and ask your pharmacy if you are unsure.

The general rule

Semaglutide is stored refrigerated before first use. Brief, unavoidable time at room temperature is usually acceptable within the manufacturer's stated limits, but repeated or prolonged heat exposure can degrade the peptide. Never expose it to direct sun, hot cars, or freezing.

When in doubt, ask

Because limits differ between brand-name pens and compounded vials, the label and pharmacy instructions that came with your medication are the authority. If your medication was exposed to extreme heat or an unknown length of time out of the fridge, contact your pharmacy or GOAL.MD before using it.

Medically reviewed by Dr. Michael Mimlitz, MD (NPI 1508891870), Chief Physician of GOAL.MD. Physician-supervised telehealth. More at goal.md/answers.