How much weight can you lose on tirzepatide?

In clinical studies of brand-name tirzepatide, participants lost on average roughly 15% to 22% of their body weight over about 72 weeks at higher doses, alongside diet and activity changes. Individual results vary widely and depend on dose, adherence, nutrition, and physiology. Weight loss is not guaranteed, and results should always be pursued under physician supervision.

What the research shows

Tirzepatide is a dual GIP/GLP-1 receptor agonist. In the SURMOUNT-1 trial of brand-name tirzepatide, adults without diabetes lost an average of about 15% to 21% of body weight over 72 weeks depending on dose, when combined with lifestyle changes. These are averages — some people lose more, some less.

What affects your results

Your starting weight, the dose you reach, how consistently you take it, your protein and calorie intake, sleep, activity, and individual metabolism all influence outcomes. A physician tailors the plan to you and monitors progress over time.

Compounded tirzepatide is not FDA-approved. Any weight-loss result depends on the individual and is not guaranteed.

Medically reviewed by Dr. Michael Mimlitz, MD (NPI 1508891870), Chief Physician of GOAL.MD. Physician-supervised telehealth. More at goal.md/answers.