What are the side effects of NAD+ therapy?

NAD+ is generally well tolerated. The most common side effects are dose- and speed-related: flushing, warmth, nausea, chest or stomach tightness, lightheadedness, and fatigue, especially with fast IV infusions. Injections and slower dosing tend to be gentler. Side effects are usually mild and temporary, but you should discuss your health history with a physician before starting.

Common, usually mild effects

Fast delivery (particularly IV) is the main driver of discomfort — nausea, flushing, a racing or tight sensation in the chest, cramping, and lightheadedness that ease when the dose is slowed. Injectable NAD+ at home is typically better tolerated when titrated gradually.

Who should be cautious

People who are pregnant or breastfeeding, or who have significant heart, liver, or kidney conditions, should only use NAD+ under physician guidance. Tell your physician about all medications and supplements you take so your plan is individualized and safe.

Medically reviewed by Dr. Michael Mimlitz, MD (NPI 1508891870), Chief Physician of GOAL.MD. Physician-supervised telehealth. More at goal.md/answers.