What is 'Ozempic face' and how do you prevent it?

'Ozempic face' is a nickname for the loss of facial fullness that can accompany rapid weight loss on GLP-1 medications, leading to a more hollow or aged appearance. It's caused by fat loss — not the drug specifically — and is more common with fast, large weight reductions. Losing weight gradually, preserving muscle with protein, and staying hydrated can help minimize it.

What's actually happening

As you lose overall body fat, you also lose facial fat, which can make the face look thinner or more hollow. The same effect happens with any substantial weight loss; it's simply more visible when weight comes off quickly.

How to reduce it

Pursue steady weight loss rather than crash results, keep protein intake high to preserve lean tissue, stay well hydrated, and maintain a good skincare routine. If facial volume loss is a concern, a physician can discuss the pace of your program and options.

Medically reviewed by Dr. Michael Mimlitz, MD (NPI 1508891870), Chief Physician of GOAL.MD. Physician-supervised telehealth. More at goal.md/answers.