What is the starting dose of tirzepatide?

Injectable tirzepatide is typically started at a low dose — commonly 2.5 mg once weekly — and increased gradually, often every 4 weeks, under physician supervision to improve tolerability. The starting dose and titration schedule are individualized. Your physician determines what's appropriate for you; do not adjust the dose yourself.

The step-up approach

Like semaglutide, tirzepatide is titrated slowly. Starting low and increasing gradually reduces gastrointestinal side effects while your body adapts to the medication before reaching an effective maintenance dose.

Follow your physician's plan

Your ideal dose depends on your response, tolerability, and health history. Compounded tirzepatide may be dosed differently than brand-name product and is not FDA-approved. Always follow the exact schedule your physician provides.

Medically reviewed by Dr. Michael Mimlitz, MD (NPI 1508891870), Chief Physician of GOAL.MD. Physician-supervised telehealth. More at goal.md/answers.